解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Long-gap esophageal atresia (LGEA) may have clinical and syndromic presentations different from those of esophageal atresia (EA) that affects shorter segments of the esophagus (non-LGEA). This may suggest unique underlying developmental mechanisms. OBJECTIVES:We sought to characterize clinical differences b...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000449241
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90/min to the current 3:1 compression:ventilation ratio (C:V). OBJECTIVE:To determine whet...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000477998
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES:To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000452195
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurological morbidity in infants and children. Oxidative stress due to free radical formation and the initiation of abnormal oxidative reactions appears to play a key role. Docosahexanoic acid (DHA), a main component of ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000454982
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Surface temperatures of fibreoptic phototherapy pads using a high intensity blue light-emitting diode (LED) light source have not been studied. OBJECTIVES:The aim of this study was to measure the temperature of LED fibreoptic phototherapy pads during phototherapy in a bench-top study, and to determine tempe...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000464318
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Congenital diaphragmatic hernia (CDH) is an abnormal development of the diaphragm leading to high neonatal mortality and morbidity. Beyond the neonatal period, prospective data on overall long-term outcome in CDH survivors is scarce. In particular, for those treated with fetoscopic endoluminal tracheal occlu...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000479145
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Recurrent and prolonged seizures are harmful for the developing brain, emphasizing the importance of early seizure recognition and effective therapy. Amplitude-integrated electroencephalography (aEEG) has become a valuable tool to diagnose epileptic seizures, and, in parallel, genetic etiologies are increasi...
journal_title:Neonatology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478651
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Restrictive use of invasive mechanical ventilation (IMV) in preterm infants reduces the risk of bronchopulmonary dysplasia (BPD). Our objective was to determine its effect on neurodevelopmental impairment (NDI) at 24 months' corrected age (CA). METHODS:This retrospective single-center cohort s...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000471841
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. OBJECTIVES:To study the inflammatory, structural and functional effects of caffeine in an animal mode...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000442937
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Substantial health care resources are expended on standardised formal neonatal resuscitation training (SFNRT) programmes, but their effectiveness has not been proven. OBJECTIVES:To determine whether SFNRT programmes reduce neonatal mortality and morbidity, improve acquisition and retention of knowledge and ...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000443875
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge of brain injury is important to guide therapeutic decisions and reliably inform the parents. Increased secretoneurin levels have been detected in adult patients suffering from brain injury an...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000444245
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP). OBJECTIVE:To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established. METHODS:From a retrospective cohort of preterm infants with a gestationa...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000444006
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Transcutaneous bilirubin (TcB) devices are commonly used for screening of hyperbilirubinemia in term and near-term infants not exposed to phototherapy. However, the accuracy of TcB devices in infants exposed to phototherapy is unclear. OBJECTIVES:To conduct a systematic review of studies comparing TcB devic...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000442195
更新日期:2016-01-01 00:00:00
abstract::Mechanical ventilation is a risk factor for cerebral inflammation and brain injury in preterm neonates. The risk increases proportionally with the intensity of treatment. Recent studies have shown that cerebral inflammation and injury can be initiated in the delivery room. At present, initiation of intermittent positi...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000444918
更新日期:2016-01-01 00:00:00
abstract::There is mounting evidence that early continuous positive airway pressure (CPAP) from birth is feasible and safe even in very preterm infants. However, many infants will develop respiratory distress syndrome (RDS) and require surfactant treatment. Combining a noninvasive ventilation approach with a strategy for surfac...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000381122
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Brain vulnerability in the critically ill preterm newborn may be related to the burden of cerebral hypoxygenation and hypoperfusion during the immediate postnatal period. OBJECTIVE:We determined the association between adverse outcomes [death or high grade intraventricular hemorrhage (IVH)] and continuous c...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000438452
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Oral propranolol has improved the treatment of infantile hemangiomas, and a pediatric oral solution of propranolol has recently been licensed in the USA and Europe. In very preterm infants, infantile hemangiomas are associated with the occurrence of retinopathy of prematurity (ROP), and both diseases share...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381659
更新日期:2015-01-01 00:00:00
abstract::Transcutaneous electromyography of the diaphragm (dEMG) is a noninvasive and easy applicable tool to measure the electrical activity of the diaphragm. dEMG monitoring has recently been introduced in the neonatal intensive care unit as a novel cardiorespiratory monitor providing direct information on diaphragmatic brea...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000381207
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The incidence of adverse tracheal intubation-associated events (TIAEs) and associated patient, practice, and intubator characteristics in the neonatal intensive care unit (NICU) setting are unknown. OBJECTIVES:To determine the incidence of adverse TIAEs and to identify factors associated with TIAEs in the N...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000381252
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000435770
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Strategies for oxygen therapy for preterm infants, such as the Vermont-Oxford's 'Breathsavers' guidelines, seek to strike a balance between the potential risks of the extremes of hyperoxia and hypoxia in preterm infants. Using an algorithm based on those guidelines, we aimed to compare the proportion of time...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000368295
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Streptococcus agalactiae (group B Streptococcus, GBS) is the most common cause of early neonatal infection, but restricting the diagnosis to culture-positive infants may underestimate the burden of GBS disease. Our objective was to determine whether maternal GBS colonization was associated with an increased ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000434716
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Hyperglycaemia is a common complication of prematurity and is associated with neonatal mortality and morbidity, yet the aetiology is incompletely understood. C-peptide has been used in adults to estimate endogenous insulin secretion due to its simple clearance kinetics. OBJECTIVE:To determine insulin secret...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381206
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Periventricular white matter (PWM) is particularly vulnerable in very preterm infants. Non-cystic white matter injury, known as non-cystic periventricular leukomalacia (ncPVL), is the commonest 'lesion' affecting the preterm brain. There is no consensus about whether ncPVL can be reliably identified from cer...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000357937
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:High-dose dexamethasone (DXM) treatment of preterms at risk of bronchopulmonary dysplasia leads to a deterioration in quality of their general movements (GMs). It is unknown whether low-dose DXM affects GM quality similarly. OBJECTIVES:To assess the effect of low-dose DXM treatment on the quality of GMs and...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000362919
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Meconium displaces surfactant from the alveolar surface and inhibits its function. The development of active synthetic surfactants is complicated, especially to synthesize the hydrophobic surfactant proteins SP-B and SP-C. A synthetic surfactant, CHF5633 containing SP-B and SP-C analogs, has been designed to...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000356065
更新日期:2014-01-01 00:00:00
abstract::The aim of this article is to educate neonatal caregivers about metagenomics. This scientific field uses novel and ever changing molecular methods to identify how infants become colonized with microbes after birth. Publications using metagenomics appear infrequently in the neonatal literature because clinicians are un...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000354944
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Preterm birth contributes significantly to infant mortality and morbidity, including blindness from retinopathy of prematurity (ROP). Access to intensive neonatal care is expanding in many countries, but care is not always optimal, one factor being that nursing is often by inadequately trained nurse assistan...
journal_title:Neonatology
pub_type: 临床试验,杂志文章
doi:10.1159/000362532
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Preterm infants are at greater risk of developmental impairment and require close follow-up for early and optimal care. OBJECTIVES:The objective of the present study was to determine from which age the parental Ages and Stages Questionnaire (ASQ) allows detection of school difficulties in preterm children <...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000363216
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. OBJECTIVE:This study aims to estimate the incidence of NEC in a large cohort of ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000356033
更新日期:2014-01-01 00:00:00
abstract::We describe a case highlighting several controversial and important topics regarding neonatal cardiopulmonary resuscitation (CPR). Current neonatal guidelines recommend a 3:1 compression:ventilation ratio; however, the most effective ratio of delivering chest compressions (CC) remains controversial. We report a case o...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000357609
更新日期:2014-01-01 00:00:00
abstract::Treatment of retinopathy of prematurity (ROP) is currently evolving. Novel therapeutic options are emerging that have the potential to complement existing therapies and improve treatment outcomes. However, any new therapeutic option must be thoroughly evaluated before existing (and successful) treatment paradigms can ...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000365132
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. OBJECTIVE:To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. METHODS:...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000351297
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Clinical illness caused by resistant bacteria usually represents a wider problem of asymptomatic colonization. Active surveillance with appropriate institution of isolation precautions represents a potential mechanism to control colonization and reduce infection. The neonatal intensive care unit (NICU) is an...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000343150
更新日期:2013-01-01 00:00:00
abstract::The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as ...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000349942
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Newborns are susceptible to inflammatory diseases due to defects in clearing activated immune cells from tissues. Therefore, mechanisms have likely evolved to protect neonates from leukocyte-mediated cytotoxicity. Bilirubin has antioxidant activity, and it is possible that it also exerts effects on cellular ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000343097
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT is more effective when started early. METHODS:Eighty cooled newborns were analyzed and grouped according to when cooling was started after birth: early (≤180 min) or late (>181 min...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000353948
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Targeted milrinone treatment for low left ventricular output (LVO) reduces the incidence of acute cardiorespiratory instability following ligation of patent ductus arteriosus (PDA) in preterm infants. Despite this, some infants continue to experience postoperative deterioration. Adrenal insufficiency related...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000350017
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE:We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000342632
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Preterm infants with signs of poor perfusion are often treated with volume expansion, although evidence regarding its effect on cerebral perfusion is lacking. Moreover, the effect is questionable in preterm infants with an adequate cerebrovascular autoregulation (CAR). A useful measure to assess perfusion is...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000346383
更新日期:2013-01-01 00:00:00